Cargando…

Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine

BACKGROUND: Our previous research demonstrated that one subcutaneous injection of 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) 24 hours (h) before irradiation (8.75 Gy) increased mouse survival by 75%. However, the protective mechanism of 17-DMAG is currently unknown. The present st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Xinyue, Nurmemet, Dilber, Bolduc, David L, Elliott, Thomas B, Kiang, Juliann G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852109/ https://www.ncbi.nlm.nih.gov/pubmed/24499553 http://dx.doi.org/10.1186/2045-3701-3-36

Ejemplares similares

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors
por: Aregbe, Abdulateef O., et al.
Publicado: (2012)

Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin inhibits the proliferation of ARPE-19 cells
por: Yao, Jia-Qi, et al.
Publicado: (2010)

Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease
por: Ho, Shuk Wai, et al.
Publicado: (2013)

Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells
por: Zhao, Xuerong, et al.
Publicado: (2017)

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin
por: Wu, X, et al.
Publicado: (2009)

The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer
por: Roh, J-L, et al.
Publicado: (2013)

Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells
por: Musha, Atsushi, et al.
Publicado: (2012)

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy
por: Rodrigues, Loreta M, et al.
Publicado: (2012)

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
por: Karkoulis, Panagiotis K, et al.
Publicado: (2010)

17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation
por: Kiang, Juliann G, et al.
Publicado: (2011)

Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy
por: Refos, Jeannine M., et al.
Publicado: (2017)

Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen: Mechanisms of Remodeling of Tissue Barriers in Sepsis
por: Gorbunov, Nikolai V., et al.
Publicado: (2013)

Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters
por: Pastvova, Nikola, et al.
Publicado: (2021)

Radioprotective potential of histamine on rat small intestine and uterus
por: Carabajal, E., et al.
Publicado: (2012)

Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells
por: Kim, Hyun-Ji, et al.
Publicado: (2007)

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2
por: Brandes, Alissa H, et al.
Publicado: (2010)

Bone Marrow Mesenchymal Stem Cells Increase Survival after Ionizing Irradiation Combined with Wound Trauma: Characterization and Therapy
por: Kiang, Juliann G, et al.
Publicado: (2014)

Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity
por: Byon, Yun-Young, et al.
Publicado: (2008)

P17 All in the Marrow - A case of Primary Bone Marrow Oedema
por: Koshy, Varghese, et al.
Publicado: (2022)

Radioprotective effects of vitamin A against gamma radiation in mouse bone marrow cells
por: Changizi, Vahid, et al.
Publicado: (2019)

Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury
por: Kiang, Juliann G., et al.
Publicado: (2014)

Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound
por: Kiang, Juliann G., et al.
Publicado: (2018)

Control of T(H)17 cells occurs in the Small Intestine
por: Esplugues, Enric, et al.
Publicado: (2011)

Rheumatoid arthritis bone marrow environment supports Th17 response
por: Kuca-Warnawin, Ewa, et al.
Publicado: (2017)

Ciprofloxacin Modulates Cytokine/Chemokine Profile in Serum, Improves Bone Marrow Repopulation, and Limits Apoptosis and Autophagy in Ileum after Whole Body Ionizing Irradiation Combined with Skin-Wound Trauma
por: Fukumoto, Risaku, et al.
Publicado: (2013)

Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn
por: Kiang, Juliann G., et al.
Publicado: (2014)

A Review of Clinical Radioprotection and Chemoprotection for Oral Mucositis
por: Oronsky, Bryan, et al.
Publicado: (2018)

La radioprotection
por: Bonet-Maury, P
Publicado: (1969)

Nonmicrobial Activation of TLRs Controls Intestinal Growth, Wound Repair, and Radioprotection
por: Stenson, William F., et al.
Publicado: (2021)

Released dsDNA‐triggered inflammasomes serve as intestinal radioprotective targets
por: Chen, Long, et al.
Publicado: (2023)

Bone marrow-derived stem cells ameliorate hepatic fibrosis by down-regulating interleukin-17
por: Zheng, Linhua, et al.
Publicado: (2013)

Abstract 17: Increasing Ischemia Time Diminishes Chimerism After Vascularized Bone Marrow Allotransplantation
por: Do, Nicholas, et al.
Publicado: (2019)

Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury
por: Liu, Dengqun, et al.
Publicado: (2010)

Exercices de radioprotection
por: Ammerich, Marc
Publicado: (2019)

Congrès de radioprotection
Publicado: (1971)

Radioprotection et radiothérapie
Publicado: (1975)

Manuel de radioprotection
por: CERN. Geneva
Publicado: (1983)

Bone destruction by Th17
por: Williams, Ruth
Publicado: (2006)

Interleukin-17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages
por: Song, Lu, et al.
Publicado: (2019)

Radioprotective Effects of Sulfur-containing Mineral Water of Ramsar Hot Spring with High Natural Background Radiation on Mouse Bone Marrow Cells
por: Heidari, A.H., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kg7tuolkon5mbbrs0tokpkree6