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Systematic Construction of Kinetic Models from Genome-Scale Metabolic Networks
The quantitative effects of environmental and genetic perturbations on metabolism can be studied in silico using kinetic models. We present a strategy for large-scale model construction based on a logical layering of data such as reaction fluxes, metabolite concentrations, and kinetic constants. The...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852239/ https://www.ncbi.nlm.nih.gov/pubmed/24324546 http://dx.doi.org/10.1371/journal.pone.0079195 |