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Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors
BACKGROUND: Intratumoral heterogeneity is a major obstacle for the treatment of cancer, as the presence of even minor populations that are insensitive to therapy can lead to disease relapse. Increased clonal diversity has been correlated with a poor prognosis for cancer patients, and we therefore ex...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852494/ https://www.ncbi.nlm.nih.gov/pubmed/24119551 http://dx.doi.org/10.1186/1755-8794-6-40 |