Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated FGFR3 si...

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Detalles Bibliográficos
Autores principales: Matsushita, Masaki, Kitoh, Hiroshi, Ohkawara, Bisei, Mishima, Kenichi, Kaneko, Hiroshi, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852501/
https://www.ncbi.nlm.nih.gov/pubmed/24324705
http://dx.doi.org/10.1371/journal.pone.0081569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852501/
https://www.ncbi.nlm.nih.gov/pubmed/24324705
http://dx.doi.org/10.1371/journal.pone.0081569

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