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Embryonic stem cells shed new light on the developmental roles of p53
The viability and subtle developmental defects of p53 knockout mice suggest that p53 does not play major role in development. However, contradictory evidence also exists. This discrepancy mainly results from the lack of molecular and cellular mechanisms and the general fact that p53 activation requi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852614/ https://www.ncbi.nlm.nih.gov/pubmed/24171803 http://dx.doi.org/10.1186/2045-3701-3-42 |
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author | Shin, Min Hwa He, Yunlong Huang, Jing |
author_facet | Shin, Min Hwa He, Yunlong Huang, Jing |
author_sort | Shin, Min Hwa |
collection | PubMed |
description | The viability and subtle developmental defects of p53 knockout mice suggest that p53 does not play major role in development. However, contradictory evidence also exists. This discrepancy mainly results from the lack of molecular and cellular mechanisms and the general fact that p53 activation requires stresses. Recent studies of p53 in mouse and human ES cells and induced pluripotent stem (iPS) cells shed new light on the mechanisms of the developmental roles of p53. This review summarizes these new studies that support the developmental roles of p53, highlights the possible underlying molecular mechanisms, and discusses the potential relationship between the developmental roles and the tumor suppressive function of p53. In summary, the molecular mechanisms underlying the developmental roles of p53 are emerging, and the developmental roles and tumor suppressive function of p53 may be closely related. |
format | Online Article Text |
id | pubmed-3852614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38526142013-12-06 Embryonic stem cells shed new light on the developmental roles of p53 Shin, Min Hwa He, Yunlong Huang, Jing Cell Biosci Review The viability and subtle developmental defects of p53 knockout mice suggest that p53 does not play major role in development. However, contradictory evidence also exists. This discrepancy mainly results from the lack of molecular and cellular mechanisms and the general fact that p53 activation requires stresses. Recent studies of p53 in mouse and human ES cells and induced pluripotent stem (iPS) cells shed new light on the mechanisms of the developmental roles of p53. This review summarizes these new studies that support the developmental roles of p53, highlights the possible underlying molecular mechanisms, and discusses the potential relationship between the developmental roles and the tumor suppressive function of p53. In summary, the molecular mechanisms underlying the developmental roles of p53 are emerging, and the developmental roles and tumor suppressive function of p53 may be closely related. BioMed Central 2013-10-09 /pmc/articles/PMC3852614/ /pubmed/24171803 http://dx.doi.org/10.1186/2045-3701-3-42 Text en Copyright © 2013 Shin et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Shin, Min Hwa He, Yunlong Huang, Jing Embryonic stem cells shed new light on the developmental roles of p53 |
title | Embryonic stem cells shed new light on the developmental roles of p53 |
title_full | Embryonic stem cells shed new light on the developmental roles of p53 |
title_fullStr | Embryonic stem cells shed new light on the developmental roles of p53 |
title_full_unstemmed | Embryonic stem cells shed new light on the developmental roles of p53 |
title_short | Embryonic stem cells shed new light on the developmental roles of p53 |
title_sort | embryonic stem cells shed new light on the developmental roles of p53 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852614/ https://www.ncbi.nlm.nih.gov/pubmed/24171803 http://dx.doi.org/10.1186/2045-3701-3-42 |
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