Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

BACKGROUND: Unexpected cholestasis substantially contributes to drug failure in clinical trials. Current models used for safety assessment in drug development do not accurately predict cholestasis in humans. Therefore, it is of relevance to develop new screening models that allow identifying drugs w...

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Detalles Bibliográficos
Autores principales: Szalowska, Ewa, Stoopen, Geert, Groot, Maria J, Hendriksen, Peter JM, Peijnenburg, Ad ACM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852711/
https://www.ncbi.nlm.nih.gov/pubmed/24112857
http://dx.doi.org/10.1186/1755-8794-6-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852711/
https://www.ncbi.nlm.nih.gov/pubmed/24112857
http://dx.doi.org/10.1186/1755-8794-6-39

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