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Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes
BACKGROUND: Unexpected cholestasis substantially contributes to drug failure in clinical trials. Current models used for safety assessment in drug development do not accurately predict cholestasis in humans. Therefore, it is of relevance to develop new screening models that allow identifying drugs w...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852711/ https://www.ncbi.nlm.nih.gov/pubmed/24112857 http://dx.doi.org/10.1186/1755-8794-6-39 |