Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

BACKGROUND: The involvement of protein kinase CK2 in sustaining cancer cell survival could have implications also in the resistance to conventional and unconventional therapies. Moreover, CK2 role in blood tumors is rapidly emerging and this kinase has been recognized as a potential therapeutic targ...

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Detalles Bibliográficos
Autores principales: Quotti Tubi, Laura, Gurrieri, Carmela, Brancalion, Alessandra, Bonaldi, Laura, Bertorelle, Roberta, Manni, Sabrina, Pavan, Laura, Lessi, Federica, Zambello, Renato, Trentin, Livio, Adami, Fausto, Ruzzene, Maria, Pinna, Lorenzo A, Semenzato, Gianpietro, Piazza, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852751/
https://www.ncbi.nlm.nih.gov/pubmed/24283803
http://dx.doi.org/10.1186/1756-8722-6-78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852751/
https://www.ncbi.nlm.nih.gov/pubmed/24283803
http://dx.doi.org/10.1186/1756-8722-6-78

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