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Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): implications for the origin and emergence of Middle East respiratory syndrome coronavirus

BACKGROUND: The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) that first appeared in Saudi Arabia during the summer of 2012 has to date (20th September 2013) caused 58 human deaths. MERS-CoV utilizes the dipeptidyl peptidase 4 (DPP4) host cell receptor, and analysis of the lo...

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Detalles Bibliográficos
Autores principales: Cui, Jie, Eden, John-Sebastian, Holmes, Edward C, Wang, Lin-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852826/
https://www.ncbi.nlm.nih.gov/pubmed/24107353
http://dx.doi.org/10.1186/1743-422X-10-304