Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

The ATP:ADP ratio is a critical parameter of cellular energy status that regulates many metabolic activities. Here we report an optimized genetically-encoded fluorescent biosensor, PercevalHR, that senses the ATP:ADP ratio. PercevalHR is tuned to the range of intracellular ATP:ADP expected in mammal...

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Detalles Bibliográficos
Autores principales: Tantama, Mathew, Martínez-François, Juan Ramón, Mongeon, Rebecca, Yellen, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852917/
https://www.ncbi.nlm.nih.gov/pubmed/24096541
http://dx.doi.org/10.1038/ncomms3550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852917/
https://www.ncbi.nlm.nih.gov/pubmed/24096541
http://dx.doi.org/10.1038/ncomms3550

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