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Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)
The amyloid precursor protein (APP) and its processing by the α-, β- and γ-secretases is widely believed to play a central role during the development of Alzheimer´s disease. The three-dimensional structure of the entire protein, its physiologic function and the regulation of its proteolytic process...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852973/ https://www.ncbi.nlm.nih.gov/pubmed/24324731 http://dx.doi.org/10.1371/journal.pone.0081926 |