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Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)

The amyloid precursor protein (APP) and its processing by the α-, β- and γ-secretases is widely believed to play a central role during the development of Alzheimer´s disease. The three-dimensional structure of the entire protein, its physiologic function and the regulation of its proteolytic process...

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Detalles Bibliográficos
Autores principales:	Coburger, Ina, Dahms, Sven O., Roeser, Dirk, Gührs, Karl-Heinz, Hortschansky, Peter, Than, Manuel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852973/ https://www.ncbi.nlm.nih.gov/pubmed/24324731 http://dx.doi.org/10.1371/journal.pone.0081926

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