Top3β is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation

Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3β (Top3β) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein deficient in Fragile X syndrome and known to regul...

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Detalles Bibliográficos
Autores principales: Xu, Dongyi, Shen, Weiping, Guo, Rong, Xue, Yutong, Peng, Wei, Sima, Jian, Yang, Jay, Sharov, Alexei, Srikantan, Subramanya, Yang, Jiandong, Fox, David, Qian, Yong, Martindale, Jennifer L., Piao, Yulan, Machamer, James, Joshi, Samit R., Mohanty, Subhasis, Shaw, Albert C., Lloyd, Thomas E., Brown, Grant W., Ko, Minoru S.H., Gorospe, Myriam, Zou, Sige, Wang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853347/
https://www.ncbi.nlm.nih.gov/pubmed/23912945
http://dx.doi.org/10.1038/nn.3479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853347/
https://www.ncbi.nlm.nih.gov/pubmed/23912945
http://dx.doi.org/10.1038/nn.3479

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