Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

BACKGROUND: 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU a...

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Detalles Bibliográficos
Autores principales: Hsieh, Chen-Hsi, Hou, Mei-Ling, Chiang, Meng-Hsuan, Tai, Hung-Chi, Tien, Hui-Ju, Wang, Li-Ying, Tsai, Tung-Hu, Chen, Yu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853440/
https://www.ncbi.nlm.nih.gov/pubmed/24066670
http://dx.doi.org/10.1186/1479-5876-11-231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853440/
https://www.ncbi.nlm.nih.gov/pubmed/24066670
http://dx.doi.org/10.1186/1479-5876-11-231

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