Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors

BACKGROUND: Alzheimer’s disease (AD) is characterized by progressive memory loss and impaired cognitive function. Early-onset familial forms of the disease (FAD) are caused by inheritance of mutant genes encoding presenilin 1 (PS1) variants. We have demonstrated that prion promoter (PrP)-driven expr...

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Detalles Bibliográficos
Autores principales: Veeraraghavalu, Karthikeyan, Choi, Se Hoon, Zhang, Xiaoqiong, Sisodia, Sangram S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853710/
https://www.ncbi.nlm.nih.gov/pubmed/24138759
http://dx.doi.org/10.1186/1750-1326-8-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853710/
https://www.ncbi.nlm.nih.gov/pubmed/24138759
http://dx.doi.org/10.1186/1750-1326-8-41

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