Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery

A fundamental role of the Hsp90-Cdc37 chaperone system in mediating maturation of protein kinase clients and supporting kinase functional activity is essential for the integrity and viability of signaling pathways involved in cell cycle control and organism development. Despite significant advances...

Descripción completa

Detalles Bibliográficos
Autores principales: Lawless, Nathan, Blacklock, Kristin, Berrigan, Elizabeth, Verkhivker, Gennady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854018/
https://www.ncbi.nlm.nih.gov/pubmed/24287464
http://dx.doi.org/10.3390/ph6111407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854018/
https://www.ncbi.nlm.nih.gov/pubmed/24287464
http://dx.doi.org/10.3390/ph6111407

Ejemplares similares