Cargando…
TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I
The phosphorylation of cardiac troponin I (cTnI) plays an important role in the contractile dysfunction associated with heart failure. Human cardiac troponin I-interacting kinase (TNNI3K) is a novel cardiac-specific functional kinase that can bind to cTnI in a yeast two-hybrid screen. The purpose of...
Autores principales: | Wang, Hui, Wang, Lin, Song, Li, Zhang, Yan-Wan, Ye, Jue, Xu, Rui-Xia, Shi, Na, Meng, Xian-Min |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854359/ https://www.ncbi.nlm.nih.gov/pubmed/23369981 http://dx.doi.org/10.1590/1414-431X20122515 |
Ejemplares similares
-
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)
por: Asquith, Christopher R. M., et al.
Publicado: (2020) -
De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents
por: Hassoun, Roua, et al.
Publicado: (2021) -
Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
por: Siddiqui, Jalal K., et al.
Publicado: (2016) -
A case report of recessive restrictive cardiomyopathy caused by a novel mutation in cardiac troponin I (TNNI3)
por: Pantou, Malena P., et al.
Publicado: (2019) -
Identification of a nonsense mutation in TNNI3K associated with cardiac conduction disease
por: Liu, Jiang, et al.
Publicado: (2020)