A Multiplexed Fluorescent Calcium and NFAT Reporter Gene Assay to Identify GPCR Agonists

Intracellular calcium response and resulting calcium signaling to an agonist-GPCR interaction are important for the measurement of compound activity in the GPCR drug development. The increase in cytosol calcium concentration can be measured by the fluorescent calcium indicator dye such as Fluo-4 in...

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Detalles Bibliográficos
Autores principales: Sheth, Heeral, Gorey, Colleen, Roush, Nicole, Smallman, Shelly, Collantes, Elizabeth, Santoro, Maxine, Olson, Barbara, Fitzgerald, Laura, Lee, Paul H, Shen, Xiqiang John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854663/
https://www.ncbi.nlm.nih.gov/pubmed/24396729
http://dx.doi.org/10.2174/2213988501307010001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854663/
https://www.ncbi.nlm.nih.gov/pubmed/24396729
http://dx.doi.org/10.2174/2213988501307010001

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