Cargando…

A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK)

AMPK is a conserved heterotrimeric serine-threonine kinase that regulates anabolic and catabolic pathways in eukaryotes. Its central role in cellular and whole body metabolism makes AMPK a commonly proposed therapeutic target for illnesses characterized by abnormal energy regulation, including cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sinnett, Sarah E, Sexton, Jonathan Z, Brenman, Jay E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Open 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854666/ https://www.ncbi.nlm.nih.gov/pubmed/24396733 http://dx.doi.org/10.2174/2213988501307010030

Ejemplares similares

Isolation of AMP-activated protein kinase (AMPK) alleles required for neuronal maintenance in Drosophila melanogaster
por: Swick, Lance L., et al.
Publicado: (2013)

Homogenous Fluorescent Assays for Characterizing Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK)
por: Reichling, Laurie J, et al.
Publicado: (2008)

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase
por: Kazgan, Nevzat, et al.
Publicado: (2010)

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission
por: Plouffe, David M., et al.
Publicado: (2016)

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)
por: Grempler, Rolf, et al.
Publicado: (2018)

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
por: Gu, Xin, et al.
Publicado: (2017)

Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis
por: Chen, Jin, et al.
Publicado: (2023)

A High Throughput Serum Paraoxonase Assay for Discovery of Small Molecule Modulators of PON1 Activity
por: Graves, Tiffany L, et al.
Publicado: (2008)

A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK)
por: Yan, Yan, et al.
Publicado: (2017)

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
por: Ramamurthy, Santosh, et al.
Publicado: (2012)

Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction
por: Yang, Weina, et al.
Publicado: (2020)

Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens
por: Clausse, Victor, et al.
Publicado: (2019)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Discovery of Novel Small Molecules for Heart Failure Therapy Using Cultured Cardiomyocyte by High Throughput Screening Assay
por: Shimizu, Satoshi, et al.
Publicado: (2021)

AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
por: Jhaveri, Teraneh Z., et al.
Publicado: (2015)

AMP-Activated Kinase AMPK Is Expressed in Boar Spermatozoa and Regulates Motility
por: Hurtado de Llera, Ana, et al.
Publicado: (2012)

Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
por: Andrade, Bruno Moulin, et al.
Publicado: (2014)

AMP-Activated Protein Kinase (AMPK)-Dependent Regulation of Renal Transport
por: Glosse, Philipp, et al.
Publicado: (2018)

LKB1 and AMPK maintain epithelial cell polarity under energetic stress
por: Mirouse, Vincent, et al.
Publicado: (2007)

LKB1 and AMPK maintain epithelial cell polarity under energetic stress
por: Mirouse, Vincent, et al.
Publicado: (2013)

High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
por: Aseeri, Mazen, et al.
Publicado: (2022)

The mucolipidosis IV Ca(2+) channel TRPML1 (MCOLN1) is regulated by the TOR kinase
por: Onyenwoke, Rob U., et al.
Publicado: (2015)

A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists
por: Tsalkova, Tamara, et al.
Publicado: (2012)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Activation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells
por: Wu, Yong, et al.
Publicado: (2012)

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly
por: Hinchy, Elizabeth C., et al.
Publicado: (2018)

Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
por: Kanagaki, Shuhei, et al.
Publicado: (2023)

Leveraging family-specific signatures for AMP discovery and high-throughput annotation
por: Waghu, Faiza Hanif, et al.
Publicado: (2016)

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein
por: Carver, Joseph, et al.
Publicado: (2014)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

A High Throughput Assay to Identify Small Molecule Modulators of Prostatic Acid Phosphatase
por: Larsen, Rylan S, et al.
Publicado: (2009)

A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp
por: Bhattacharyya, Nisan, et al.
Publicado: (2014)

AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis
por: Onyenwoke, Rob U., et al.
Publicado: (2012)

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
por: Yamada, Eijiro, et al.
Publicado: (2016)

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity
por: Rubio, Teresa, et al.
Publicado: (2013)

Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema
por: Lee, Jae Seung, et al.
Publicado: (2015)

Involvement of 5′AMP-Activated Protein Kinase (AMPK) in the Effects of Resveratrol on Liver Steatosis
por: Trepiana, Jenifer, et al.
Publicado: (2018)

Retraction: Activation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells
Publicado: (2020)

Phenotypic Fingerprinting of Small Molecule Cell Cycle Kinase Inhibitors for Drug Discovery
por: Low, Jonathan, et al.
Publicado: (2009)

Functional recombinant MHC class II molecules and high-throughput peptide-binding assays
por: Justesen, Sune, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_6dupsq29ok1ch7368bf8no3e9l