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Somatic mtDNA Mutation Spectra in the Aging Human Putamen

The accumulation of heteroplasmic mitochondrial DNA (mtDNA) deletions and single nucleotide variants (SNVs) is a well-accepted facet of the biology of aging, yet comprehensive mutation spectra have not been described. To address this, we have used next generation sequencing of mtDNA-enriched librari...

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Detalles Bibliográficos
Autores principales:	Williams, Siôn L., Mash, Deborah C., Züchner, Stephan, Moraes, Carlos T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854840/ https://www.ncbi.nlm.nih.gov/pubmed/24339796 http://dx.doi.org/10.1371/journal.pgen.1003990

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