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Somatic mtDNA Mutation Spectra in the Aging Human Putamen
The accumulation of heteroplasmic mitochondrial DNA (mtDNA) deletions and single nucleotide variants (SNVs) is a well-accepted facet of the biology of aging, yet comprehensive mutation spectra have not been described. To address this, we have used next generation sequencing of mtDNA-enriched librari...
| Prif Awduron: | , , , |
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| Fformat: | Online Erthygl Texto |
| Iaith: | English |
| Cyhoeddwyd: |
Public Library of Science
2013
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| Pynciau: | |
| Mynediad Ar-lein: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854840/ https://www.ncbi.nlm.nih.gov/pubmed/24339796 http://dx.doi.org/10.1371/journal.pgen.1003990 |