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Genome-Wide Screen Reveals Replication Pathway for Quasi-Palindrome Fragility Dependent on Homologous Recombination

Inverted repeats capable of forming hairpin and cruciform structures present a threat to chromosomal integrity. They induce double strand breaks, which lead to gross chromosomal rearrangements, the hallmarks of cancers and hereditary diseases. Secondary structure formation at this motif has been pro...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Saini, Natalie, Sheng, Ziwei, Lobachev, Kirill S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855049/
https://www.ncbi.nlm.nih.gov/pubmed/24339793
http://dx.doi.org/10.1371/journal.pgen.1003979