The Proteasome Inhibitor Bortezomib Induces an Inhibitory Chromatin Environment at a Distal Enhancer of the Estrogen Receptor-α Gene

Expression of the estrogen receptor-α (ERα) gene, ESR1, is a clinical biomarker used to predict therapeutic outcome of breast cancer. Hence, there is significant interest in understanding the mechanisms regulating ESR1 gene expression. Proteasome activity is increased in cancer and we previously sho...

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Detalles Bibliográficos
Autores principales: Powers, Ginny L., Rajbhandari, Prashant, Solodin, Natalia M., Bickford, Brant, Alarid, Elaine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855213/
https://www.ncbi.nlm.nih.gov/pubmed/24339902
http://dx.doi.org/10.1371/journal.pone.0081110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855213/
https://www.ncbi.nlm.nih.gov/pubmed/24339902
http://dx.doi.org/10.1371/journal.pone.0081110

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