HIV-1 Replication Fitness of HLA-B*57/58:01 CTL Escape Variants Is Restored by the Accumulation of Compensatory Mutations in Gag

Expression of HLA-B*57 and the closely related HLA-B*58:01 are associated with prolonged survival after HIV-1 infection. However, large differences in disease course are observed among HLA-B*57/58:01 patients. Escape mutations in CTL epitopes restricted by these HLA alleles come at a fitness cost an...

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Detalles Bibliográficos
Autores principales: Gijsbers, Esther F., Feenstra, K. Anton, van Nuenen, Ad C., Navis, Marjon, Heringa, Jaap, Schuitemaker, Hanneke, Kootstra, Neeltje A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855271/
https://www.ncbi.nlm.nih.gov/pubmed/24339913
http://dx.doi.org/10.1371/journal.pone.0081235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855271/
https://www.ncbi.nlm.nih.gov/pubmed/24339913
http://dx.doi.org/10.1371/journal.pone.0081235

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