Meningeal myeloma deposits adversely impact the therapeutic index of an oncolytic VSV

Vesicular Stomatitis Virus (VSV) is neuropathogenic in rodents but can be attenuated 50-fold by engineering the mouse interferon-beta (IFN-β) gene into its genome. Intravenously administered VSVs encoding IFN-β have potent activity against subcutaneous tumors in the 5TGM1 mouse myeloma model, withou...

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Detalles Bibliográficos
Autores principales: Yarde, Danielle N., Naik, Shruthi, Nace, Rebecca A., Peng, Kah-Whye, Federspiel, Mark J., Russell, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855306/
https://www.ncbi.nlm.nih.gov/pubmed/24176894
http://dx.doi.org/10.1038/cgt.2013.63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855306/
https://www.ncbi.nlm.nih.gov/pubmed/24176894
http://dx.doi.org/10.1038/cgt.2013.63

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