Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung

CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CCR4-mediated recruitment of immune cells. CCL17 sha...

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Detalles Bibliográficos
Autores principales: Santulli-Marotto, Sandra, Boakye, Ken, Lacy, Eilyn, Wu, Sheng-Jiun, Luongo, Jennifer, Kavalkovich, Karl, Coelho, Ana, Hogaboam, Cory M., Ryan, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855316/
https://www.ncbi.nlm.nih.gov/pubmed/24339934
http://dx.doi.org/10.1371/journal.pone.0081465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855316/
https://www.ncbi.nlm.nih.gov/pubmed/24339934
http://dx.doi.org/10.1371/journal.pone.0081465

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