Role of IGF-Binding Protein 3 in the Resistance of EGFR Mutant Lung Cancer Cells to EGFR-Tyrosine Kinase Inhibitors

Most patients treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) eventually develop acquired resistance. Loss of expression of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) has been suggested as a possible mechanism of resistance to EGFR-TKIs in the A431 and HN11 cell lines. Her...

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Detalles Bibliográficos
Autores principales: Choi, Yun Jung, Park, Gun Min, Rho, Jin Kyung, Kim, Sun Ye, So, Gwang Sup, Kim, Hyeong Ryul, Choi, Chang-Min, Lee, Jae Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855319/
https://www.ncbi.nlm.nih.gov/pubmed/24339922
http://dx.doi.org/10.1371/journal.pone.0081393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855319/
https://www.ncbi.nlm.nih.gov/pubmed/24339922
http://dx.doi.org/10.1371/journal.pone.0081393

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