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Role of IGF-Binding Protein 3 in the Resistance of EGFR Mutant Lung Cancer Cells to EGFR-Tyrosine Kinase Inhibitors

Most patients treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) eventually develop acquired resistance. Loss of expression of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) has been suggested as a possible mechanism of resistance to EGFR-TKIs in the A431 and HN11 cell lines. Her...

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Detalles Bibliográficos
Autores principales:	Choi, Yun Jung, Park, Gun Min, Rho, Jin Kyung, Kim, Sun Ye, So, Gwang Sup, Kim, Hyeong Ryul, Choi, Chang-Min, Lee, Jae Cheol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855319/ https://www.ncbi.nlm.nih.gov/pubmed/24339922 http://dx.doi.org/10.1371/journal.pone.0081393

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