Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis

NF-κB is a key transcription factor that regulates innate immune response. Its activity is tightly controlled by numerous feedback loops, including two negative loops mediated by NF-κB inducible inhibitors, IκBα and A20, which assure oscillatory responses, and by positive feedback loops arising due...

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Detalles Bibliográficos
Autores principales: Pękalski, Jakub, Zuk, Pawel J., Kochańczyk, Marek, Junkin, Michael, Kellogg, Ryan, Tay, Savaş, Lipniacki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855823/
https://www.ncbi.nlm.nih.gov/pubmed/24324544
http://dx.doi.org/10.1371/journal.pone.0078887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855823/
https://www.ncbi.nlm.nih.gov/pubmed/24324544
http://dx.doi.org/10.1371/journal.pone.0078887

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