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Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
NF-κB is a key transcription factor that regulates innate immune response. Its activity is tightly controlled by numerous feedback loops, including two negative loops mediated by NF-κB inducible inhibitors, IκBα and A20, which assure oscillatory responses, and by positive feedback loops arising due...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855823/ https://www.ncbi.nlm.nih.gov/pubmed/24324544 http://dx.doi.org/10.1371/journal.pone.0078887 |