Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca(2+) overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca(2+) channel (VDC) and Na(+)/Ca(2+) exchanger (NCX) system are the main pathways of intracellular Ca(...

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Detalles Bibliográficos
Autores principales: Yang, Dingping, Yang, Dingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855990/
https://www.ncbi.nlm.nih.gov/pubmed/24350283
http://dx.doi.org/10.1155/2013/678456
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author Yang, Dingping
Yang, Dingwei
author_facet Yang, Dingping
Yang, Dingwei
author_sort Yang, Dingping
collection PubMed
description The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca(2+) overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca(2+) channel (VDC) and Na(+)/Ca(2+) exchanger (NCX) system are the main pathways of intracellular Ca(2+) overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca(2+) overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.
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spelling pubmed-38559902013-12-16 Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury Yang, Dingping Yang, Dingwei Biomed Res Int Review Article The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca(2+) overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca(2+) channel (VDC) and Na(+)/Ca(2+) exchanger (NCX) system are the main pathways of intracellular Ca(2+) overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca(2+) overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder. Hindawi Publishing Corporation 2013 2013-11-18 /pmc/articles/PMC3855990/ /pubmed/24350283 http://dx.doi.org/10.1155/2013/678456 Text en Copyright © 2013 D. Yang and D. Yang. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Dingping
Yang, Dingwei
Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury
title Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury
title_full Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury
title_fullStr Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury
title_full_unstemmed Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury
title_short Role of Intracellular Ca(2+) and Na(+)/Ca(2+) Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury
title_sort role of intracellular ca(2+) and na(+)/ca(2+) exchanger in the pathogenesis of contrast-induced acute kidney injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855990/
https://www.ncbi.nlm.nih.gov/pubmed/24350283
http://dx.doi.org/10.1155/2013/678456
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