Cargando…
Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins. In the current study, we aimed to identify autophagy inducers from Chinese medicinal herbs as a potential neuroprotective agent tha...
Autores principales: | Wu, An-Guo, Wong, Vincent Kam-Wai, Xu, Su-Wei, Chan, Wai-Kit, Ng, Choi-In, Liu, Liang, Law, Betty Yuen-Kwan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856081/ https://www.ncbi.nlm.nih.gov/pubmed/24248062 http://dx.doi.org/10.3390/ijms141122618 |
Ejemplares similares
-
Neferine Attenuates the Protein Level and Toxicity of Mutant Huntingtin in PC-12 Cells via Induction of Autophagy
por: Wong, Vincent Kam Wai, et al.
Publicado: (2015) -
Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins
por: Wu, An-Guo, et al.
Publicado: (2015) -
Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments
por: Li, Xiaohang, et al.
Publicado: (2016) -
Intestinal Absorption Profile of Three Polygala Oligosaccharide Esters in Polygalae Radix and the Effects of Other Components in Polygalae Radix on Their Absorption
por: Ba, YinYing, et al.
Publicado: (2019) -
Chromatographic analysis of Polygalae Radix by online hyphenating pressurized liquid extraction
por: Song, Yuelin, et al.
Publicado: (2016)