Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening

Hepatitis C virus (HCV) NS3/NS4A serine protease is essential for viral replication, which is regarded as a promising drug target for developing direct-acting anti-HCV agents. In this study, sixteen novel compounds with cell-based HCV replicon activity ranging from 3.0 to 28.2 μM (IC(50)) were succe...

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Detalles Bibliográficos
Autores principales: Li, Jing, Liu, Xian, Li, Shanshan, Wang, Yulan, Zhou, Nannan, Luo, Cheng, Luo, Xiaomin, Zheng, Mingyue, Jiang, Hualiang, Chen, Kaixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856094/
https://www.ncbi.nlm.nih.gov/pubmed/24264035
http://dx.doi.org/10.3390/ijms141122845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856094/
https://www.ncbi.nlm.nih.gov/pubmed/24264035
http://dx.doi.org/10.3390/ijms141122845

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