Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant inactivated in AnsP1 revealed the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the...

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Detalles Bibliográficos
Autores principales: Gouzy, Alexandre, Larrouy-Maumus, Gérald, Wu, Ting-Di, Peixoto, Antonio, Levillain, Florence, Lugo-Villarino, Geanncarlo, Gerquin-Kern, Jean-Luc, de Carvalho, Luiz Pedro Sório, Poquet, Yannick, Neyrolles, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856356/
https://www.ncbi.nlm.nih.gov/pubmed/24077180
http://dx.doi.org/10.1038/nchembio.1355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856356/
https://www.ncbi.nlm.nih.gov/pubmed/24077180
http://dx.doi.org/10.1038/nchembio.1355

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