Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant inactivated in AnsP1 revealed the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the...

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Autores principales: Gouzy, Alexandre, Larrouy-Maumus, Gérald, Wu, Ting-Di, Peixoto, Antonio, Levillain, Florence, Lugo-Villarino, Geanncarlo, Gerquin-Kern, Jean-Luc, de Carvalho, Luiz Pedro Sório, Poquet, Yannick, Neyrolles, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856356/
https://www.ncbi.nlm.nih.gov/pubmed/24077180
http://dx.doi.org/10.1038/nchembio.1355
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author Gouzy, Alexandre
Larrouy-Maumus, Gérald
Wu, Ting-Di
Peixoto, Antonio
Levillain, Florence
Lugo-Villarino, Geanncarlo
Gerquin-Kern, Jean-Luc
de Carvalho, Luiz Pedro Sório
Poquet, Yannick
Neyrolles, Olivier
author_facet Gouzy, Alexandre
Larrouy-Maumus, Gérald
Wu, Ting-Di
Peixoto, Antonio
Levillain, Florence
Lugo-Villarino, Geanncarlo
Gerquin-Kern, Jean-Luc
de Carvalho, Luiz Pedro Sório
Poquet, Yannick
Neyrolles, Olivier
author_sort Gouzy, Alexandre
collection PubMed
description Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant inactivated in AnsP1 revealed the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus.
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spelling pubmed-38563562014-05-01 Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate Gouzy, Alexandre Larrouy-Maumus, Gérald Wu, Ting-Di Peixoto, Antonio Levillain, Florence Lugo-Villarino, Geanncarlo Gerquin-Kern, Jean-Luc de Carvalho, Luiz Pedro Sório Poquet, Yannick Neyrolles, Olivier Nat Chem Biol Article Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant inactivated in AnsP1 revealed the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus. 2013-09-29 2013-11 /pmc/articles/PMC3856356/ /pubmed/24077180 http://dx.doi.org/10.1038/nchembio.1355 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gouzy, Alexandre
Larrouy-Maumus, Gérald
Wu, Ting-Di
Peixoto, Antonio
Levillain, Florence
Lugo-Villarino, Geanncarlo
Gerquin-Kern, Jean-Luc
de Carvalho, Luiz Pedro Sório
Poquet, Yannick
Neyrolles, Olivier
Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
title Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
title_full Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
title_fullStr Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
title_full_unstemmed Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
title_short Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
title_sort mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856356/
https://www.ncbi.nlm.nih.gov/pubmed/24077180
http://dx.doi.org/10.1038/nchembio.1355
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