Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio

The objectives of this work were the formulation optimization of the preparation process parameters and to evaluate spray-dried sustained-release microspheres using ammonio methacrylate copolymer (AMC) as a polymer matrix. The effects of log P and the concentrations of the cosolvents (acetone, methy...

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Detalles Bibliográficos
Autores principales: Sipos, Péter, Rajkó, Róbert, Pintye-Hódi, Klára, Erős, István, Szabó-Révész, Piroska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857060/
https://www.ncbi.nlm.nih.gov/pubmed/24309310
http://dx.doi.org/10.3390/pharmaceutics3040830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857060/
https://www.ncbi.nlm.nih.gov/pubmed/24309310
http://dx.doi.org/10.3390/pharmaceutics3040830

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