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Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency
Four guanidine derivatives of N(4), N(9)-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N(1),N(12)-diamidino-N(4), N(9)-dioleoylspermine and N(1)...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857073/ https://www.ncbi.nlm.nih.gov/pubmed/24310587 http://dx.doi.org/10.3390/pharmaceutics3030406 |