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Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency

Four guanidine derivatives of N(4), N(9)-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N(1),N(12)-diamidino-N(4), N(9)-dioleoylspermine and N(1)...

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Detalles Bibliográficos
Autores principales:	Metwally, Abdelkader A., Blagbrough, Ian S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857073/ https://www.ncbi.nlm.nih.gov/pubmed/24310587 http://dx.doi.org/10.3390/pharmaceutics3030406

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