Development and characterization of gastroretentive sustained-release formulation by combination of swelling and mucoadhesive approach: a mechanistic study

BACKGROUND: Acyclovir has pharmacokinetic limitations, including poor oral bioavailability of 15%–30%, high variability, and short elimination half-life of 2.3 hours. These limitations necessitate frequent administration of acyclovir, up to five times daily, leading to poor patient compliance, which...

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Detalles Bibliográficos
Autores principales: Sankar, R, Jain, Subheet Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857114/
https://www.ncbi.nlm.nih.gov/pubmed/24348022
http://dx.doi.org/10.2147/DDDT.S52890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857114/
https://www.ncbi.nlm.nih.gov/pubmed/24348022
http://dx.doi.org/10.2147/DDDT.S52890

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