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The α and Δ Isoforms of CREB1 Are Required to Maintain Normal Pulmonary Vascular Resistance

Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional mechanisms responsible for these distinctive changes are unclear. We have previously reported that CREB1 is activated in the lung in response...

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Detalles Bibliográficos
Autores principales: Li, Lili, Howell, Katherine, Sands, Michelle, Banahan, Mark, Frohlich, Stephen, Rowan, Simon C., Neary, Roisín, Ryan, Donal, McLoughlin, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857174/
https://www.ncbi.nlm.nih.gov/pubmed/24349008
http://dx.doi.org/10.1371/journal.pone.0080637