Dispersion Estimation and Its Effect on Test Performance in RNA-seq Data Analysis: A Simulation-Based Comparison of Methods

A central goal of RNA sequencing (RNA-seq) experiments is to detect differentially expressed genes. In the ubiquitous negative binomial model for RNA-seq data, each gene is given a dispersion parameter, and correctly estimating these dispersion parameters is vital to detecting differential expressio...

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Detalles Bibliográficos
Autores principales: Landau, William Michael, Liu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857202/
https://www.ncbi.nlm.nih.gov/pubmed/24349066
http://dx.doi.org/10.1371/journal.pone.0081415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857202/
https://www.ncbi.nlm.nih.gov/pubmed/24349066
http://dx.doi.org/10.1371/journal.pone.0081415

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