Cargando…

Inhibition of DNA Glycosylases via Small Molecule Purine Analogs

Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potential targets in combination chemotherapeutic strategies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jacobs, Aaron C., Calkins, Marcus J., Jadhav, Ajit, Dorjsuren, Dorjbal, Maloney, David, Simeonov, Anton, Jaruga, Pawel, Dizdaroglu, Miral, McCullough, Amanda K., Lloyd, R. Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857224/ https://www.ncbi.nlm.nih.gov/pubmed/24349107 http://dx.doi.org/10.1371/journal.pone.0081667

Ejemplares similares

Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations
por: Zuckerman, Jamie T., et al.
Publicado: (2023)

Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection
por: Dorjsuren, Dorjbal, et al.
Publicado: (2012)

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ
por: Yamanaka, Kinrin, et al.
Publicado: (2012)

Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity
por: Marsden, Carolyn G., et al.
Publicado: (2020)

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)
por: Sommers, Joshua A., et al.
Publicado: (2019)

Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines
por: Jaruga, Pawel, et al.
Publicado: (2010)

Linking uracil base excision repair and 5-fluorouracil toxicity in yeast
por: Seiple, Lauren, et al.
Publicado: (2006)

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity
por: Dorjsuren, Dorjbal, et al.
Publicado: (2011)

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model
por: Dorjsuren, Dorjbal, et al.
Publicado: (2022)

Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO(3)) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts
por: Gassman, Natalie R., et al.
Publicado: (2016)

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1
por: Simeonov, Anton, et al.
Publicado: (2009)

Thymine DNA glycosylase as a novel target for melanoma
por: Mancuso, Pietro, et al.
Publicado: (2019)

Polyamines stimulate the formation of mutagenic 1,N(2)-propanodeoxyguanosine adducts from acetaldehyde
por: Theruvathu, Jacob A., et al.
Publicado: (2005)

Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937
por: Nyaga, Simon G, et al.
Publicado: (2006)

Significant disparity in base and sugar damage in DNA resulting from neutron and electron irradiation
por: Pang, Dalong, et al.
Publicado: (2014)

Inhibition of human APE1 and MTH1 DNA repair proteins by dextran-coated γ-Fe(2)O(3) ultrasmall superparamagnetic iron oxide nanoparticles
por: Coskun, Erdem, et al.
Publicado: (2023)

Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
por: Kirkali, Güldal, et al.
Publicado: (2013)

Bisphenol A Promotes Cell Survival Following Oxidative DNA Damage in Mouse Fibroblasts
por: Gassman, Natalie R., et al.
Publicado: (2015)

Possible Genetic Risks from Heat-Damaged DNA in Food
por: Jun, Yong Woong, et al.
Publicado: (2023)

Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound
por: Malins, Donald C., et al.
Publicado: (2006)

Synthesis and Characterization of (15)N(5)-Labeled Aflatoxin B(1)–Formamidopyrimidines and Aflatoxin B(1)–N7-Guanine from a Partial Double-Stranded Oligodeoxynucleotide as Internal Standards for Mass Spectrometric Measurements
por: Jaruga, Pawel, et al.
Publicado: (2023)

FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers
por: Mesquita, Katia A., et al.
Publicado: (2021)

Ne-22 Ion-Beam Radiation Damage to DNA: From Initial Free Radical Formation to Resulting DNA-Base Damage
por: Kant, Melis, et al.
Publicado: (2021)

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases
por: Dorjsuren, Dorjbal, et al.
Publicado: (2009)

High-Throughput 1,536-Well Fluorescence Polarization Assays for α(1)-Acid Glycoprotein and Human Serum Albumin Binding
por: Yasgar, Adam, et al.
Publicado: (2012)

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity
por: Yasgar, Adam, et al.
Publicado: (2017)

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase
por: Cole, Ambrose R., et al.
Publicado: (2013)

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity
por: Yasgar, Adam, et al.
Publicado: (2018)

Suppression of the FOXM1 transcriptional program via novel small molecule inhibition
por: Gormally, Michael V., et al.
Publicado: (2014)

Diverse models for anti-HIV activity of purine nucleoside analogs
por: Khatri, Naveen, et al.
Publicado: (2015)

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
por: Šála, Michal, et al.
Publicado: (2016)

PB1867: PURINE ANALOGS ON HAIRY CELL LEUKAEMIA TREATMENT
por: Gomes, G., et al.
Publicado: (2022)

DNA glycosylases: in DNA repair and beyond
por: Jacobs, Angelika L., et al.
Publicado: (2011)

Exploiting Purine as an Internal Standard for SERS Quantification of Purine Derivative Molecules Released by Bacteria
por: Cheng, Ho-Wen, et al.
Publicado: (2023)

A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System
por: Cheng, Eric, et al.
Publicado: (2022)

Covalent Small Molecule Inhibitors of Ca(2+)-Bound S100B
por: Cavalier, Michael C., et al.
Publicado: (2014)

Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007
por: Liu, Gaofei, et al.
Publicado: (2019)

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein
por: Carver, Joseph, et al.
Publicado: (2014)

Noncatalytic Domains in DNA Glycosylases
por: Torgasheva, Natalia A., et al.
Publicado: (2022)

Inhibitors of DNA Glycosylases as Prospective Drugs
por: Mechetin, Grigory V., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4skrt8pu0cbua5m8g0lgq1act1