The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response

All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant – mecA or mecC - which encode for a low affinity penicillin binding protein –PBP2A or PBP2A′ – that can continue the catalysis of peptidoglycan transpeptidation in the presence of high concentrations of beta-lac...

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Detalles Bibliográficos
Autores principales: Kim, Choonkeun, Mwangi, Michael, Chung, Marilyn, Milheirço, Catarina, de Lencastre, Herminia, Tomasz, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857269/
https://www.ncbi.nlm.nih.gov/pubmed/24349368
http://dx.doi.org/10.1371/journal.pone.0082814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857269/
https://www.ncbi.nlm.nih.gov/pubmed/24349368
http://dx.doi.org/10.1371/journal.pone.0082814

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