Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics

The effect of omeprazole on the mitochondrial carnitine/acylcarnitine transporter has been studied in proteoliposomes. Externally added omeprazole inhibited the carnitine/carnitine antiport catalysed by the transporter. The inhibition was partially reversed by DTE indicating that it was caused by th...

Descripción completa

Detalles Bibliográficos
Autores principales: Tonazzi, Annamaria, Eberini, Ivano, Indiveri, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857281/
https://www.ncbi.nlm.nih.gov/pubmed/24349247
http://dx.doi.org/10.1371/journal.pone.0082286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857281/
https://www.ncbi.nlm.nih.gov/pubmed/24349247
http://dx.doi.org/10.1371/journal.pone.0082286

Ejemplares similares