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Inflammasome-Mediated Inhibition of Listeria monocytogenes-Stimulated Immunity Is Independent of Myelomonocytic Function
Activation of the Nlrc4 inflammasome results in the secretion of IL-1β and IL-18 through caspase-1 and induction of pyroptosis. L. monocytogenes engineered to activate Nlrc4 by expression of Legionella pneumophilia flagellin (L. monocytogenes L.p.FlaA) are less immunogenic for CD8(+) T cell response...
| Автори: | , , |
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| Формат: | Online Стаття Текст |
| Мова: | English |
| Опубліковано: |
Public Library of Science
2013
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| Предмети: | |
| Онлайн доступ: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857309/ https://www.ncbi.nlm.nih.gov/pubmed/24349458 http://dx.doi.org/10.1371/journal.pone.0083191 |