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β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications

Increasing evidence points to nuclear compartmentalization as a contributing mechanism for gene regulation, yet mechanisms for compartmentalization remain unclear. In this paper, we use autonomous targeting of bacterial artificial chromosome (BAC) transgenes to reveal cis requirements for peripheral...

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Detalles Bibliográficos
Autores principales: Bian, Qian, Khanna, Nimish, Alvikas, Jurgis, Belmont, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857487/
https://www.ncbi.nlm.nih.gov/pubmed/24297746
http://dx.doi.org/10.1083/jcb.201305027