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Attenuation of Eph Receptor Kinase Activation in Cancer Cells by Coexpressed Ephrin Ligands
The Eph receptor tyrosine kinases mediate juxtacrine signals by interacting “in trans” with ligands anchored to the surface of neighboring cells via a GPI-anchor (ephrin-As) or a transmembrane segment (ephrin-Bs), which leads to receptor clustering and increased kinase activity. Additionally, solubl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857839/ https://www.ncbi.nlm.nih.gov/pubmed/24348920 http://dx.doi.org/10.1371/journal.pone.0081445 |