Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

P-glycoprotein (Pgp, ABCB1) is an ATP-Binding Cassette (ABC) transporter that is associated with the development of multidrug resistance in cancer cells. Pgp transports a variety of chemically dissimilar amphipathic compounds using the energy from ATP hydrolysis. In the present study, to elucidate t...

Descripción completa

Detalles Bibliográficos
Autores principales: Chufan, Eduardo E., Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T., Durell, Stewart R., Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857843/
https://www.ncbi.nlm.nih.gov/pubmed/24349290
http://dx.doi.org/10.1371/journal.pone.0082463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857843/
https://www.ncbi.nlm.nih.gov/pubmed/24349290
http://dx.doi.org/10.1371/journal.pone.0082463

Ejemplares similares