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Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

P-glycoprotein (Pgp, ABCB1) is an ATP-Binding Cassette (ABC) transporter that is associated with the development of multidrug resistance in cancer cells. Pgp transports a variety of chemically dissimilar amphipathic compounds using the energy from ATP hydrolysis. In the present study, to elucidate t...

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Detalles Bibliográficos
Autores principales:	Chufan, Eduardo E., Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T., Durell, Stewart R., Ambudkar, Suresh V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857843/ https://www.ncbi.nlm.nih.gov/pubmed/24349290 http://dx.doi.org/10.1371/journal.pone.0082463

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