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Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20

The translocation of macromolecules into the nucleus is a fundamental eukaryotic process, regulating gene expression, cell division and differentiation, but which is impaired in a range of significant diseases including cancer and viral infection. The import of proteins into the nucleus is generally...

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Detalles Bibliográficos
Autores principales: Roman, Noelia, Christie, Mary, Swarbrick, Crystall M. D., Kobe, Bostjan, Forwood, Jade K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858281/
https://www.ncbi.nlm.nih.gov/pubmed/24339986
http://dx.doi.org/10.1371/journal.pone.0082038